Plaque rupture and intimal neovascularization
نویسندگان
چکیده
منابع مشابه
Deletion of Sema4D gene reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process of tumor growth. To clarify the roles of Sema4D in the progression of atheros...
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The interactions between the renin-angiotensin system and neovascularization in atherosclerotic plaque development are unclear. We investigated the effects of angiotensin II type 1 receptor antagonism in the pathogenesis of atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice with a special focus on plaque neovascularization. ApoE(-/-) mice fed a high-fat diet were randomly assigned t...
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Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel wall, is a physiological response to mechanical injury, increased wall stress, or chemical insult (e.g., atherosclerosis). If excessive, it can lead to the obstruction of blood flow and tissue ischemia. Together with expansive or constrictive remodeling, the extent of intimal expansion determines fina...
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Angiogenesis, the formation of new blood vessels from preexisting ones, is an important phenomenon in various physiological processes, such as embryonic development and pathological conditions, including acute and chronic inflammatory processes, such as wound healing, rheumatoid arthritis, diabetic retinopathy, and tumor progression.1 Plaque neovascularization, first described by Koester more t...
متن کامل4 Atherosclerotic plaque rupture
The arterial system is more than an intricate plumbing system for the transport of blood; it is a highly complex organ that interacts with its environment. The major function of the vessel wall, and more specifically the endothelial lining, is to maintain an adequate blood supply to the end organ that it is supplying. This is achieved by regulatory mechanisms that control vascular tone, inflamm...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1998
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.25.6-7_263